Endometriosis

Endometriosis is a long-term condition where tissue similar to the lining of the womb (endometrium) grows outside the uterus. These growths most commonly appear on the ovaries, fallopian tubes, or pelvic walls.

This misplaced tissue responds to monthly hormonal changes just like the uterine lining, where it thickens, breaks down and bleeds with each menstrual cycle. However, because the blood and tissue have no way to leave the body, they become trapped within the pelvic cavity, leading to inflammation, irritation, scar tissue (adhesions) and pain.

It is estimated that 1 in 10 women of reproductive age is affected by endometriosis globally, and similar rates are seen in Singapore. Despite this, many cases go undiagnosed for years due to overlapping symptoms with other pelvic or digestive conditions.

The condition can range from mild to severe. Some women experience debilitating menstrual or pelvic pain, while others may have minimal symptoms despite extensive disease. Beyond physical discomfort, endometriosis can also influence fertility, emotional well-being and daily quality of life, making early recognition and management essential.

endometriosis Singapore
Endometriosis affects an estimated 1 in 10 women of reproductive age in Singapore, though many remain undiagnosed due to overlapping symptoms with other pelvic conditions.

What are the stages of Endometriosis?

The condition is classified into 4 stages based on the spread, depth and extent of lesions and adhesions:

STAGE SEVERITY DESCRIPTION
1 Minimal Small, shallow spots or implants may appear on the pelvic lining or organs. Symptoms may still be significant despite minimal disease seen on imaging or laparoscopy.
2 Mild More lesions appear, some of which may be deeper. Minor adhesions can begin to form around the reproductive organs.
3 Moderate Multiple deep lesions and thicker adhesions develop, often affecting the ovaries and fallopian tubes. This can start to distort normal pelvic anatomy and cause fertility issues.
4 Severe Extensive implants, large ovarian cysts (endometriomas), and dense adhesions may involve several pelvic organs, such as the uterus, bladder and bowels. This stage often causes significant pain and reduces fertility.

It is important to note that the stage of the disease does not always reflect symptom severity. Someone with mild endometriosis may have intense pain, while another with advanced disease may feel little discomfort.

What causes Endometriosis?

The exact causes remain unclear, but severe biological mechanisms may explain how the condition develops. This includes:

  • Cell transformation (metaplasia) – certain pelvic cells may transform into endometrial-like tissue under hormonal or inflammatory influence.
  • Hormonal influence – oestrogen promotes the survival and growth of endometrial tissue outside the uterus.
  • Immune dysfunction – the immune system fails to clear displaced endometrial cells, allowing them to persist and form lesions.
  • Retrograde menstruation – menstrual blood flows backwards through the fallopian tubes into the pelvic cavity, carrying endometrial cells that implant and grow.
  • Post-surgical spread – procedures such as C-sections or pelvic surgery may inadvertently transfer endometrial cells to new sites.


These mechanisms ultimately create chronic inflammation and fibrosis, leading to pain, stiffness and impaired organ function.

How does Endometriosis impact quality of life?

Endometriosis can impact various aspects of daily life, including physical well-being, emotional health, and work productivity. Persistent pain, fatigue and unpredictable symptoms often interfere with routine activities, exercise and intimacy. Many women also report heightened anxiety, frustration or isolation due to the chronic and often invisible nature of their pain.

When the condition is left untreated, it can lead to:

  • Bowel or bladder discomfort during menstruation
  • Difficulty conceiving due to inflammation and scarring around the reproductive organs
  • Ongoing pelvic or lower back pain
  • Painful periods and pain during sex
endometriomas Singapore.
Endometriomas, or “chocolate cysts,” are fluid-filled sacs that develop when endometrial-like tissue grows on the ovaries and bleeds during each cycle, causing thick, dark fluid to collect over time.

What are the symptoms of Endometriosis?

The symptoms can vary widely and sometimes overlap with other pelvic or digestive disorders. This can often contribute to delayed diagnosis. Some of the common symptoms include:

  • Bloating and abdominal discomfort – sometimes described as “endo belly”, often mistaken for digestive issues.
  • Chronic fatigue – due to pain, inflammation, and hormonal disruption.
  • Heavy or irregular periods – with clotting or spotting between cycles.
  • Infertility or difficulty conceiving – caused by scarring or inflammation around the fallopian tubes and ovaries.
  • Pain during or after sex (dyspareunia) – caused by lesions or adhesions around the uterus and pelvic wall.
  • Painful periods (dysmenorrhoea) – cramping and deep, throbbing pain that worsens over time.
  • Pelvic pain – usually cyclical and linked to menstruation, but may also occur throughout the month.
  • Painful bowel movements or urination – especially during menstruation when inflammation peaks.

Who is at risk of developing Endometriosis?

endometriosis symptoms.
Severe menstrual cramps or unusually heavy bleeding should not be ignored, as they may signal endometriosis that requires medical attention.

While endometriosis can affect anyone who menstruates, some individuals are more likely to develop it due to a combination of genetic, hormonal and environmental factors. This includes, but is not limited to:

  • Family history – having a mother, sister or close relative with endometriosis increases the risk by two to three times. This suggests a genetic component, where inherited traits may make certain individuals more prone to inflammation or abnormal cell growth.
  • Early menstruation – beginning periods at a younger age (before 11 years old) or having shorter menstrual cycles means more lifetime menstrual cycles. This repeated hormonal activity may expose the pelvic cavity to more endometrial cells, raising the likelihood of implantation outside the womb.
  • Heavy or prolonged periods – excessive or long-lasting menstrual bleeding (menorrhagia) leads to increased retrograde menstruation, allowing endometrial-like cells to settle and grow in the surrounding tissues.
  • Reproductive history – those who have never been pregnant or given birth tend to experience more uninterrupted menstrual cycles, leading to ongoing exposure to hormonal fluctuations that can stimulate endometrial tissue growth.
  • Autoimmune or hormonal disorders – conditions that weaken immune surveillance or alter hormone balance may make it easier for misplaced endometrial cells to survive and multiply rather than being cleared from the body.
  • Environmental factors – research suggests that long-term exposure to certain environmental pollutants or endocrine-disrupting chemicals (such as dioxins) may interfere with hormone regulation and immune response, potentially contributing to the development of endometriosis.

How is Endometriosis diagnosed in Singapore?

The diagnosis typically combines careful clinical evaluation with imaging and, when needed, minimally invasive procedures. This generally entails:

  • Medical history and examination – our doctor will ask about your symptoms, menstrual history and pain triggers. A pelvic exam may detect tender spots or thickened tissue.
  • Imaging studies – an ultrasound can identify cysts or larger lesions, while a magnetic resonance imaging (MRI) provides detailed imaging for deep endometriosis affecting the bowels or bladder.
  • Laparoscopy – a thin camera is inserted through a small incision in the abdomen, allowing our doctor to visualise, and if necessary, remove or biopsy lesions for confirmation.


Why does it take so long to diagnose Endometriosis?

Many women live with endometriosis for years before diagnosis. In fact, it often takes between 7 to 10 years to reach a conclusive diagnosis. Several factors contribute to this delay, such as:

  • Variable symptom severity – pain levels do not always match the extent of the disease, confusing both the patient and doctors.
  • Normalised menstrual pain – severe period pain is often dismissed as “normal,” leading patients to delay seeking care.
  • Overlapping symptoms – endometriosis symptoms mimic conditions like irritable bowel syndrome (IBS), urinary tract infections or pelvic inflammatory disease.
  • Inconclusive imaging – small or deep-seated lesions may not appear on standard ultrasound scans.
  • Limited awareness – historically, women’s pelvic pain has been under-recognised and under-discussed in healthcare settings.

How is Endometriosis treated in Singapore?

how to improve reproductive health.
Early consultation and proactive care can help manage symptoms, protect fertility and support long-term gynaecological health and quality of life.

The treatment depends on the severity of the condition, the patient’s symptoms and fertility goals. However, it is important to understand that there is no cure for endometriosis. As such, treatment often focuses on managing the symptoms and preventing flare-ups.

This entails:

Medical management

  • Pain relief – non-steroidal anti-inflammatory drugs (NSAIDs) help reduce cramping and inflammation.
  • Hormonal therapy – birth control pills, progestins or gonadotropin-releasing hormone (GnRH) agonists suppress ovulation and slow the growth of endometrial tissue.


Minimally invasive surgery

  • Cyst removal – for endometriomas, surgical removal prevents rupture and recurrence.
  • Laparoscopic excision – removes visible endometrial tissue and scar bands, relieving pain and restoring pelvic anatomy.


Supportive pain-relief therapies

  • Physiotherapy – helps relax tight pelvic floor muscles and reduce postural strain.
  • Ultrasound-guided nerve blocks or injections – target pain-generating areas for longer-term relief.
  • Lifestyle modifications – anti-inflammatory diets, stress reduction and gentle exercise can reduce flare-ups.

When should women seek medical attention to check for endometriosis?

You should seek a medical assessment if you experience:

  • Difficulty conceiving
  • Discomfort during sex, urination or bowel movements
  • Heavy or irregular periods
  • Pain that worsens before or during menstruation
  • Persistent pelvic or lower back pain

Summary

It goes without saying that endometriosis is a complex yet manageable condition. While diagnosis is often delayed, growing awareness and better diagnostic tools are helping women find answers earlier. With the right combination of medical therapy, lifestyle care and supportive treatment, most patients achieve significant pain reduction and improved quality of life.


If you experience ongoing pelvic pain, painful periods or fertility concerns, schedule a consultation with our doctor for a personalised assessment and early treatment.

Frequently Asked Questions (FAQs)